I have been running Defensio for a week now.
253 positive spam comments and only 8 false positive hits. Not bad in my book as the current accuracy is at 97.05%.
What I seem to be loving about Defensio is it’s simplicity in spam management.

Color code comments based on spaminess
Obvious spam is hidden
Spam statistics made available through [...]

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Defensio is the latest comment spam filtering service for blogs and web applications. Blogging platforms currently supported are WordPress, PixelPost, Umbraco, Drupal, Mephisto, Movable Type and TextPattern. Web applications can see integration through the following platforms, Ruby On Rails, .Net, Java, PHP and Python.
Currently, the only big player out there doing the same is Askimet. [...]

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