1. Edit the /etc/network/interfaces file. Add mtu 9000 to the interface.
iface lo inet loopback

auto enp4s0
iface enp4s0 inet static
        mtu 9000

iface enp5s0 inet manual
  1. Restart the interface
[email protected]:~# systemctl restart networking.service 

[email protected]:~# systemctl status networking.service 
? networking.service - Network initialization
     Loaded: loaded (/lib/systemd/system/networking.service; enabled; vendor preset: enabled)
     Active: active (exited) since Sun 2022-02-13 13:03:11 CST; 14s ago
       Docs: man:interfaces(5)
    Process: 2052 ExecStart=/usr/share/ifupdown2/sbin/start-networking start (code=exited, status=0/SUCCESS)
   Main PID: 2052 (code=exited, status=0/SUCCESS)
        CPU: 476ms

Feb 13 13:03:10 pvebkpdev01 systemd[1]: Starting Network initialization...
Feb 13 13:03:10 pvebkpdev01 networking[2052]: networking: Configuring network interfaces
Feb 13 13:03:11 pvebkpdev01 systemd[1]: Finished Network initialization.

[email protected]:~# ip a list enp4s0
2: enp4s0: <BROADCAST,MULTICAST,UP,LOWER_UP> mtu 9000 qdisc mq state UP group default qlen 1000
    link/ether 00:07:43:05:b9:f4 brd ff:ff:ff:ff:ff:ff
    inet scope global enp4s0
       valid_lft forever preferred_lft forever
    inet6 fe80::207:43ff:fe05:b9f4/64 scope link 
       valid_lft forever preferred_lft forever